Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole
作者
WANG TIANSHENG; DUFFY JOHN P; WANG JIAN; HALAS SUMMER; SALITURO FRANCESCO G; PIERCE ALBERT C; ZUCCOLA HARMON J; BLACK JAMES R; HOGAN JAMES K; JEPSON SCOTT; SHLYAKTER DINA; MAHAJAN SUDIPTA; GU YONG; HOOCK THOMAS; WOOD MARK; FUREY BRINLEY F; FRANTZ J DANIEL; DAUFFENBACH LISA M; GERMANN URSULA A; FAN BIN; NAMCHUK MARK; BENNANI YOUSSEF L; LEDEBOER MARK W
[摘要]：The Synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.
