Quinolone Analogues 10: Synthesis of Antimalarial Quinolones Having Pyridyl Moiety in N1-Side Chain

[摘要]：Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1[1-ethoxycarbony1-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carbox ylate 7a was found to show antimalarial activity from the screening data.

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