Synthesis of 2[2,4-Diaminothiazol-5-oyl]benzothiazoles

[摘要]：The synthesis of 2-(4-amino-2-alkylaminothiazol-5-oyl)benzothiazoles and 2-[2,4-bis(arylamino)thiazol-5-oyl]benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2-bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type (RNH)-N-1-CS-NH-C(=NHR2)-(NHR3) to provide the four ring atoms [C4-N3-C2-S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported.

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