13-BROMOMONOCILLIN I - A NEW WNT-5A EXPRESSION INHIBITOR PRODUCED BY POCHONIA CHLAMYDOSPORIA VAR. CHLAMYDOSPORIA

[摘要]：WNT-5A is a secretory glycoprotein related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, a new compound, 13-bromomonocillin I (1), was isolated from the fermentation broth of the fungus Pochonia chlamydosporia, cultured in NaBr-supplernented medium. 13-Bromomonocillin I (1) exhibited WNT-5A expression inhibitory activity with an IC50 value of 0.25 mu M.

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