EFFICIENT SYNTHESIS OF 4-SUBSTITUTED 4,5-DIHYDROISOXAZOL-3-OLS FROM MORITA-BAYLIS-HILLMAN BROMIDES

[摘要]：An efficient synthesis of 4-substituted 4,5-dihydroisoxizol-3-ols was achieved with high regioselectivities and satisfactory yields via addition of N-hydroxyphthalimide to Morita-Baylis-Hillman (MBH) bromides with ester moiety, followed by hydrazinolysis and intramolecular cyclization. Surprised, the unexpected isoxazolidine-4-carbonitrile was obtained when using MBH bromide with nitrile moiety as substrate under the similar conditions.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内