【文章名】DIVERSITY-ORIENTED APPROACH TO 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (TIC) DERIVATIVES USING DIETHYL ACETAMIDOMALONATE AS A GLYCINE EQUIVALENT : FURTHER EXPANSION BY SUZUKI-MIYAURA CROSS-COUPLING REACTION
DIVERSITY-ORIENTED APPROACH TO 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (TIC) DERIVATIVES USING DIETHYL ACETAMIDOMALONATE AS A GLYCINE EQUIVALENT : FURTHER EXPANSION BY SUZUKI-MIYAURA CROSS-COUPLING REACTION
[摘要]:Synthesis of diverse 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and its higher analogues are reported using diethyl acetamidomalonate as a glycine equivalent. In addition, various substituted Tic derivatives are assembled by application of Suzuki-Miyaura cross-coupling reaction as a key step.