ENANTIOSELECTIVE SYNTHESIS OF 2-ARYL-2,3-DIHYDRO-4-QUINOLONES BY CHIRAL BRONSTED ACID CATALYZED INTRAMOLECULAR AZA-MICHAEL ADDITION REACTION

[摘要]：Asymmetric intramolecular aza-Michael addition of activated alpha,beta-unsaturated ketones catalyzed by chiral N-triflyl phosphoramide was realized. Enantioenriched 2-aryl-2,3-dihydroquinolin-4-ones can be obtained in excellent yields (77-98%) with up to 82% ee.

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