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SYNTHESIS OF BIS-ARYL PHOSPHATES BASED ON TRIAZINE SCAFFOLD

  作者 COURME CAROLINE; GRESH NOHAD; LENOIR CHRISTINE; VIDAL MICHEL; GARBAY CHRISTIANE; FLORENT JEANCLAUDE; BERTOUNESQUE EMMANUEL  
  选自 期刊  Heterocycles;  卷期  2010年81-4;  页码  867-882  
  关联知识点  
 

[摘要]In view of targeting the Grb2-SH2 signaling protein, the synthesis of potential ligands based on the 1,3,5-triazine scaffold bearing two phenylphosphate groups is described. The triazine functionality was introduced using an orthogonal strategy via the sulfone chemistry.

 
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