CONVENIENT SYNTHESIS OF 1,3-DIHYDROISOBENZOFURANS BY HYDRIODIC ACID-CATALYZED CYCLIZATION OF 2-VINYLBENZYL ALCOHOLS

[摘要]：A new and short process has been developed for the preparation of 1,1,3-tri- and 1,1,3,3-tetra-substituted 1,3-dihydroisobenzofurans (phthalanes) from alpha-substituted 2-bromostyrenes. The method involves addition of a-substituted 2-lithiostyrenes, generated by the bromine-lithium exchange between alpha-substituted 2-bromostyrenes and butyllithium, to aliphatic aldehydes or ketones, followed by hydriodic acid catalyzed cyclization of the resulting 2-vinylbenzyl alcohols.

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