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Synthesis of 4-substituted imidazoles via palladium-catalyzed cross-coupling reactions

  作者 Jetter, MC; Reitz, AB  
  选自 期刊  Synthesis;  卷期  1998年-6;  页码  829-831  
  关联知识点  
 

[摘要]Imidazoles bearing vinyl and aryl substitution in the 4-position can be prepared using palladium-catalyzed cross-coupling reactions of 1-tritylimidazol-4-yltin and -zinc reagents in 67-80% yield. Importantly, these coupling methods appear to be general for aryl and vinyl bromides, iodides, and triflates.

 
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