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[摘要]：A) Preparation of Alkyl, Allyl, and Aryl Bromides: Horner and co-workers demonstrated the application of triphenylphosphine dibromide for the conversion of alcohols and phenols into bromides. It has advantages over the other phosphorus-based reagents in effecting substitution without elimination or molecular rearrangement with inversion of the product configuration. It becomes the reagent of choice for the conversion of various types of alcohol-containing sensitive functionalities, such as cis double bonds and ketals, into the corresponding bromides.(6) B) Ring Opening of Aziridines: Kumar and co-workers(7) have reported the use of PPh3Br2 as highly efficient reagent for the ring opening of aziridines affording beta-bromo amines. The method works effectively for both activated and non-activated aziridines in excellent yields within a short period of time. |
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