Synthesis of Novel 3-Amino(Hydroxy)methyl-L-fuco-Azafagomines as Leads for Selective Inhibitors of alpha-L-Fucosidases

[摘要]：The synthesis of 3-substituted L-fuco-azafagomines from D-lyxose is reported. They represent the first example of aza-C-glycosides having a biimino (-NH-NH-) moiety. The key step of the synthesis is the introduction of the hydrazine moiety by reductive hydrazination of a 1-deoxy-ketohexose with tert-butyl carbazate. Their glycosidase inhibitory properties are also reported.

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