A New Synthesis of (R)-(-)-Sumanirole (PNU-95666E)

[摘要]：A twelve-step synthesis of (R)-(-)-sumanirole hydrochloride, starting from quinoline, has been achieved. The key reaction features selective epoxidation of the C3-C4 double bond of a 1,2-dihydroquinoline bearing a chiral auxiliary at N-1.

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