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Synthesis of Botryllamides and Lansiumamides via Ruthenium-Catalyzed Hydroamidation of Alkynes

  作者 GOOSSEN LUKAS J; BLANCHOT MATHIEU; ARNDT MATTHIAS; SALIH KIFAH S M  
  选自 期刊  SYNLETT;  卷期  2010年-11;  页码  1685-1687  
  关联知识点  
 

[摘要]Ruthenium-catalyzed hydroamidations of alkynes allow a concise synthetic entry to both E-and Z-configured enamide natural products. This was demonstrated by the synthesis of botryllamides C and E, lansiumamides A and B, and lansamide I in 1-3 steps and 57-98% yield from simple, commercially available precursors.

 
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