[摘要]：Synthesis, biological evaluation and structure-activity relationships for a series of novel gamma-carboline analogues of Dimebon (TM) are described. Among the studied compounds, gamma-carbolines 3{8} and 3{14} have been identified as potent small molecule antagonists of histamine H-1 (IC50 = 0.1 mu M) and serotonin 5-HT6 (IC50 = 0.37 mu M) receptors, respectively. Published by Elsevier Ltd.
