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Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol

  作者 Calderon, M; Graeser, R; Kratz, F; Haag, R  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2009年19-14;  页码  3725-3728  
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[摘要]In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented. (C) 2009 Elsevier Ltd. All rights reserved.

 
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