Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency

[摘要]：Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs with potencies of less than 500 nM in a cell based assay. The selectivity of the inhibitors can be rationalized by examination of X-ray crystal structures of inhibitors bound to MK2. (C) 2009 Elsevier Ltd. All rights reserved.

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