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Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit

作者	Zbinden, KG; Anselm, L; Banner, DW; Benz, J; Blasco, F; Decoret, G; Himber, J; Kuhn, B; Panday, N; Ricklin, F; Risch, P; Schlatter, D; Stahl, M; Thomi, S; Unger, R; Haap, W

选自	期刊 European Journal of Medicinal Chemistry; 卷期 2009年44-7; 页码 2787-2795

关联知识点

[摘要]：Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed. (C) 2009 Elsevier Masson SAS. All rights reserved.
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