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Protein tyrosine nitration-An update

  作者 Ischiropoulos, H  
  选自 期刊  Archives of Biochemistry and Biophysics ;  卷期  2009年484-2;  页码  117-121  
  关联知识点  
 

[摘要]Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses Suggesting a novel biological function for this protein modification. (C) 2008 Elsevier Inc. All rights reserved.

 
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