[摘要]：Treatment of 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline (I) with a-bromoketones in benzene in the presence of triethylamine afforded the corresponding pyrrolo[2,1-a]isoquinolines II (R = Ph, benzothiazin-2-yl, etc.). Also treatment of 3,4-dihydro-6,7-diethoxyisoquinoline-1-carbonitrile (III) with a-bromoketones under the same reaction conditions afforded the corresponding pyrroloisoquinolines. Exposure of pyrrolo[2,1-a]isoquinolines to diazoarenes produced the corresponding azo-substituted derivs., while treatment of isoquinolinium salts with p-tolyldiazonium chloride in ethanol afforded triazoloisoquinoline deriv. IV with concomitant elimination of a-bromoketones.
