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MicroRNAs repress mainly through mRNA decay.

  作者 Esslinger, Stephanie;Foerstemann, Klaus;  
  选自 期刊  Angewandte Chemie, International Edition;  卷期  2009年48-5;  页码  853-855  
  关联知识点  
 

[摘要]A review. MicroRNAs have been considered primarily as inhibitors of translation, even though degrdn. of mRNAs also plays a role in their repressive potential. Two research groups have now quantified the extent to which each mechanism contributes to gene regulation by combining mass spectrometry with transcriptome profiling. The surprising conclusion is that translational inhibition plays only a minor role.

 
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