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Strategy for the assembly of chiral bicyclic lactams: a concise synthetic route to (-)-coniceine.

  作者 Lebrun, Stephane;Couture, Axel;Deniau, Eric;Grandclaudon, Pierre;  
  选自 期刊  Synthesis;  卷期  2008年-17;  页码  2771-2775  
  关联知识点  
 

[摘要]A concise asym. synthesis of chiral bicyclic lactams combining a highly stereoselective 1,2-addn. on SAMP hydrazones with a ring-closure metathesis was achieved. The synthetic utility of this approach was emphasized by the total synthesis of (-)-coniceine in high enantiomeric excess.

 
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