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Mild and practical reductions of prochiral ketones to chiral alcohols using the chiral boronic ester TarB-H.

  作者 Eagon, Scott;Kim, Jinsoo;Singaram, Bakthan;  
  选自 期刊  Synthesis;  卷期  2008年-23;  页码  3874-3876  
  关联知识点  
 

[摘要]Chiral alcs. are prepd. under mild conditions in high enantiomeric excesses using the tartaric acid derived chiral boronic ester TarB-H. The phenylboronic acid was quant. recovered and recycled using a simple extn. with sodium hydroxide and di-Et ether. Arom. and aliph. secondary alcs. were prepd. in up to 99% ee.

 
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