[摘要]：g-Alkylidene butenolides bearing a deoxyriboside, a steroid, and a ferrocene moiety were synthesized by stereoselective sequential cross-coupling lactonization from appropriate terminal alkynes with 3-iodopropenoates. The high selectivity of the butenolide ring formation was secured by the Pd/Cu salt ratio. The resulting compds. were tested for antifungal and cytostatic properties. Most notably, g-alkylidene butenolides bearing deoxyriboside moiety showed promising cytostatic activity in the micromolar range.
