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Regiospecific bromination of 2-phenyl-3H-pyrimidin-4-ones.

  作者 Zanatta, Nilo;Fantinel, Leonardo;Fernandes, Liana da S.;Wouters, Ana D.;Bonacorso, Helio G.;Martins, Marcos A. P.;  
  选自 期刊  Synthesis;  卷期  2008年-21;  页码  3492-3496  
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[摘要]Three methods for the regiospecific bromination of 2-phenyl-3H-pyrimidin-4-ones are presented: bromination of the 5-position of the pyrimidine ring, bromination of the 6-benzylic position, and simultaneous bromination of both the 5-position of the pyrimidine ring and 6-benzylic position. Reactions were carried out using simple protocols and the brominated pyrimidines were obtained in good yields.

 
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