An efficient one-pot synthetic method for 2,4-disubstituted 7-arylpyrido[4,3-d]pyrimidines from 2,4-disubstituted 6-(arylethynyl)pyrimidine-5-carbaldehydes and tert-butylamine.

[摘要]：Unexpected thermal cyclization of 2,4-disubstituted 6-(arylethynyl)pyrimidine-5-carbaldehydes with tert-butylamine proceeded to give 2,4-disubstituted 7-arylpyrido[4,3-d]pyrimidines in good yields in the absence of any catalysts. The intermediate compds. were isolated and possible mechanism of the reactions is discussed.

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