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Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete.

  作者 Boonlarppradab, Chollaratt;Kauffman, Christopher A.;Jensen, Paul R.;Fenical, William;  
  选自 期刊  Organic Letters;  卷期  2008年10-24;  页码  5505-5508  
  关联知识点  
 

[摘要]sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 mM for I) and selective activities in diverse cancer cell types.

 
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