Biosynthetic origins of the ionophore antibiotic indanomycin.

[摘要]：The pyrroloketoindane antibiotic indanomycin is produced by Streptomyces antibioticus NRRL 8167. These hybrid nonribosomal peptide-polyketide ionophore antibiotics are characterized by the presence of an unusual indane ring system, and there is interest in identifying the biochem. mechanisms guiding its biosynthesis. Following incorporation of [1-13C]-labeled precursors, the primary metabolic origins of indanomycin were detd. to be one unit of L-proline, six units of malonyl-CoA and two units each of methylmalonyl-CoA and ethylmalonyl-CoA.

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