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Absolute Configuration of Ketone Cyanohydrins by 1H NMR: The Special Case of Polar Substituted Tertiary Alcohols.

  作者 Louzao, Iria;Garcia, Rosa;Seco, Jose Manuel;Quinoa, Emilio;Riguera, Ricardo;  
  选自 期刊  Organic Letters;  卷期  2009年11-1;  页码  53-56  
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[摘要]The abs. configuration of ketone cyanohydrins can be assigned from anal. of the 1H NMR spectra of the corresponding (R)- and (S)-MPA ester derivs. and use of DdRS signs. This is an application of the NMR methodol. for stereochem. assignment to tertiary alcs. possessing polar groups as substituents.

 
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