[摘要]：The screening for active compds. against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of 2 compds. with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 and -24 (I, R = Me and H, resp.). Their structures were established on the basis of extensive NMR and MS analyses. Both compds. exhibited cytotoxic effects against several MPM cell lines.
