Regio- and Chemoselective Synthesis of Fully Substituted Thiophenes.

[摘要]：A full functionalization of all four positions of the thiophene ring was achieved. Starting from readily available 2,5-dichlorothiophene, successive magnesiations of the 3- and 4-positions using TMPMgCl譒iCl furnish, after trapping with various electrophiles, 3,4-difunctionalized dichlorothiophenes. Subsequent dechlorination and metalation or magnesium insertion into the C-Cl bond provides fully functionalized thiophenes in high yields. An application to the synthesis of a thiophene analog of Atorvastatin (Lipitor) is reported.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内