【文章名】Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in Situ Alkylation: Utility in the Synthesis of (-)-Aspidospermidine.
Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in Situ Alkylation: Utility in the Synthesis of (-)-Aspidospermidine.
[摘要]：Chiral diether ligand-controlled asym. conjugate addn. of a lithium amide to cyclopentenecarboxylate and subsequent in situ alkylation gave a chiral cyclopentane deriv. bearing a quaternary carbon with high enantio- and diastereoselectivity. The cyclopentane deriv. was converted successfully to (-)-aspidospermidine (I).
