Designer Discodermolide Segments via Ozonolysis of Vinyl Phosphonates.

[摘要]：To apply our collection of enantiopure 7-ring vinyl sulfones to probe the anticancer SAR of a series of computer-designed (+)-discodermolide analogs, the ozonolytic reactivity of transposed cyclic vinyl phosphonates was explored. Successful prepn. of the desired aldehyde-esters and lactones from vinyl phosphonates via an oxidative cleavage-phosphite/methanol exchange sequence is described.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内