[摘要]:A new series of bis-1,2,4-trioxanes and tris-1,2,4-trioxanes were prepd. and evaluated against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. Five cyclopentane-based bis-trioxanes and three cyclohexane-based bis-trioxanes showed promising activity. All of the tris-1,2,4-trioxanes were found to be inactive. Bis-trioxane I, the most active compd. of the series, provided 100% and 80% protection to infected mice at 48 and 24 mg/kg ?4 days, resp. The clin. useful drug b-arteether provided 100% and 20% protection at similar doses.