[摘要]：A giant amphiphile consisting of polystyrene end-capped with permethylated b-cyclodextrin was synthesized and found to form vesicular structures when injected as a soln. in THF into water. The ability of the cyclodextrins on the surface of the polymersomes to form inclusion complexes with hydrophobic compds. was tested by carrying out a competition expt. with a fluorescent probe sensitive to the polarity of the surrounding medium. 1-Adamantol can displace the fluorescent probe from the cavities of the cyclodextrin moieties of the polymersomes. The recognition of mols. by cell membranes in nature is often based on interactions with specific membrane receptors. To mimic this behavior, the enzyme horseradish peroxidase was modified with adamantane groups through a poly(ethylene glycol) spacer and its interaction with the polymersomes was investigated. It was established that the presence of adamantane moieties on each enzyme allowed a host-guest interaction with the multifunctional surface of the polymersomes.
