Polyoxygenated Methyl Cyclohexanoids from a Terrestrial Ampelomyces Fungus

[摘要]：Seven structurally related new polyoxygenated methyl cyclohexanoids, ampelomins A-G (1-7), were isolated from the mycelial solid culture of a soil-derived Ampelornyces fungus. Their structures were determined by spectroscopic and chemical means. Ampelomins A (1), C (3), E (5), and G (7) exhibited weak activity against a-glucosidase with IC50 values of 1.74-5.93 mM, and ampelomin A (1) showed moderate antibacterial activity with MIC90 values ranging from 202.4 to 1015.9 mu M. A plausible polyketide biogenetic pathway is postulated for these compounds.

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