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Mixed Quantum-Classical Methods for Molecular Simulations of Biochemical Reactions With Microwave Fields: The Case Study of Myoglobin

  作者 Apollonio, F; Liberti, M; Amadei, A; Aschi, M; Pellegrino, M; D'Alessandro, M; D'Abramo, M; Di Nola, A; d'Inzeo, G  
  选自 期刊  IEEE Transactions on Microwave Theory and Techniques;  卷期  2008年56-11;  页码  2511-2519  
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[摘要]Contradictory data in the huge literature on microwaves bio-effects may result from a poor understanding of the mechanisms of interaction between microwaves and biological systems. Molecular simulations of biochemical processes seem to be a promising tool to comprehend microwave induced bio-effects. Molecular simulations of classical and quantum events involved in relevant biochemical processes enable to follow the dynamic evolution of a biochemical reaction in the presence of microwave fields. In this paper, the action of a microwave signal (1 GHz) on the covalent binding process of a ligand (carbon monoxide) to a protein (myoglobin) has been studied. Our results indicate that microwave fields, with intensities much below the atomic/molecular electric interactions, cannot affect such biochemical process.

 
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