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[摘要]：mols. of neuroscience are considerable. Most targets are complex integral membrane proteins that are not amenable to direct structural characterization. However, by combining the tools of org. synthesis, mol. biol., and electrophysiol., rational and systematic structure-function studies can be performed in what we have termed phys. org. chem. on the brain. Using these tools, we have probed hydrophobic effects, hydrogen bonding, cation-p interactions, and conformational changes assocd. with channel gating. The insights gained provide important guidance for drug discovery efforts targeting ion channels and neuroreceptors and mechanistic insights for the complex proteins of neuroscience. |
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