Nucleophilic addition of phenol derivatives to methyl 1-nitrocyclopropanecarboxylates.

[摘要]：Nucleophilic ring opening of Me 1-nitrocyclopropanecarboxylates by phenol derivs. in the presence of Cs2CO3 is described. The reaction tolerates a variety of substituents on both the arom. alc. and the cyclopropane and affords the products in good yields (53-84%) and with complete preservation of the enantiomeric excess at C-4. The methodol. was applied in an enantioselective synthesis of the norepinephrine reuptake inhibitor atomoxetine (I).

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