[摘要]：An accelerated and improved asym. synthesis of malyngamide U (I) and its 2'-epimer was accomplished from readily available n-hexanal, ethanolamine and (R)-(-)-carvone. The key steps involved a Johnson-Claisen rearrangement in the synthesis of an unsatd. carboxylic acid and an aldol reaction in the construction of the skeleton of I and its 2'-epimer. There are 13 steps in the synthesis, with a 2.7% overall yield for I and a 0.4% yield for its 2'-epimer.
