A Practical and Efficient Route for the Highly Enantioselective Synthesis of Mexiletine Analogues and Novel b-Thiophenoxy and Pyridyl Ethers.

[摘要]：A practical and efficient procedure for the enantioselective synthesis of mexiletine analogs, e.g. I, with use of 10% of spiroborate ester II as chirality transfer agent is presented. A variety of mexiletine analogs were prepd. in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodol. was also successfully applied for the synthesis of novel b-amino ethers contg. thiophenyl and pyridyl fragments.

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