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Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation.

  作者 Tsang, W. C. Peter;Munday, Rachel H.;Brasche, Gordon;Zheng, Nan;Buchwald, Stephen L.;  
  选自 期刊  Journal of Organic Chemistry;  卷期  2008年73-19;  页码  7603-7610  
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[摘要]The development of a method for the assembly of unsym. carbazoles is reported. The strategy involves the selective intramol. functionalization of an arene C-H bond and the formation of a arene C-N bond. The substitution pattern of the carbazole product can be controlled by the design of the biaryl amide substrate, and the method is compatible with a variety of functional groups. The utility of this protocol was demonstrated by the concise synthesis of three natural products from com. available materials.

 
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