Synthesis of Heavily Substituted 2-Aminopyridines by Displacement of a 6-Methylsulfinyl Group.

[摘要]：2-Aminopyridines I [R1 = NMe2, NHCH2CH2SMe, NH(CH2)3NH2, morpholine, O-allyl], with a variety of polar 6-substituents, were elaborated by displacement of a methylsulfinyl group from the 6-position of the pyridine ring. The requisite 6-thiomethyl pyridines were synthesized by reaction of 2-(1-phenylethylidene)propanedinitriles II (R2 = Me, CH2CH2CHMe2) with di-Me N-cyanodithioiminocarbonate (III).

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