Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities

[摘要]：Investigation of collagenase inhibitory natural components afforded two quinic acid esters (I and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds I and 2 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 10 mu M, and I showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC50) at 2.5 and 6.4 mu M, respectively. Copyright (C) 2007 John Wiley & Sons, Ltd.

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