Synthesis of hexahydro-1H-benzo[c]chromen-1-amines via the intramolecular ring-opening reactions of aziridines by p-nucleophiles.

[摘要]：The intramol. cyclization of aziridines with p-nucleophiles can be a useful route to a no. of heterocyclic and carbocyclic systems. This methodol. has been applied to the synthesis of hexahydro-1H-benzo[c]chromen-1-amines, the basic skeleton of many amaryllidaceae alkaloids. The success of the aziridine cyclization is largely dependent on the N-substitution of aziridine, with activated aziridines not undergoing the cyclization reaction. Only N-H-, N-alkyl- and N-arylaziridines underwent the cyclization reaction. The ring opening of an unactivated aziridines with a p-nucleophile is one of the first examples of such a reaction.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内