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A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process.

  作者 Hopkin, Mark D.;Baxendale, Ian R.;Ley, Steven V.;  
  选自 期刊  Synthesis;  卷期  2008年-11;  页码  1688-1702  
  关联知识点  
 

[摘要]Compounds (More Than One Hetero Atom)) Section A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesized amino-substituted heterocyclic compds. and intermediates involved in their formation represent novel compds. Focused microwave irradn. was used extensively to allow simple access to a wide temp. range using low b.p. solvents.

 
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