【文章名】Intramolecular palladium-catalyzed oxidative coupling on thiophene and furan rings. Determinant role of the electronic availability of the heterocycle.
Intramolecular palladium-catalyzed oxidative coupling on thiophene and furan rings. Determinant role of the electronic availability of the heterocycle.
[摘要]：The cyclization of N-allyl-N-carbethoxy-substituted aminothiophenes and furans was performed by intramol. Pd(II)-catalyzed oxidative coupling. The process involves a nucleophilic attack of a heteroarom. carbon to the internal carbon of the p-olefin complex through a 5-exo-trig ring-formation. Better conditions required PdCl2(MeCN)2 as catalyst, CuCl2 as co-catalyst and an environmentally friendly reoxidant such as O2 to promote the catalytic cycle.
