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[摘要]:The total synthesis of the natural product L-783277 I (RR1 = O) was accomplished based on the convergent assembly of appropriate building blocks. Key steps are the Suzuki coupling of olefin II and 2-trimethylsilylethyl 2-bromo-6-hydroxy-4-methoxybenzoate, the Mitsunobu-based macrolactonization of seco acid III, and the allylic oxidn. of the macrocyclic triol I (R = H, R1 = OH) with polymer-bound IBX. Only one of the two C(6')-stereoisomers of the latter product provided L-783277 with high selectivity. |
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