Total synthesis of amphidinolide X and its 12Z-isomer by formation of the C12-C13 trisubstituted double bond via ring-closing metathesis.

[摘要]：Amphidinolide X, a 16-membered cytotoxic macrodiolide, and its for assembling the C12-C13 trisubstituted double bond. A 29:71 E/Z mixt. was obtained from the seco substrate I appended with a bulky C8-ODPS group in 50-65% combined yields by using 20 mol% of the second-generation Grubbs initiator and the corresponding indenylidene ruthenium complex. Amphidinolide X and 12Z-isomer exhibit similar cytotoxicity (IC50: 7.6-13.9 mg/mL) against A549, KB, and HL60 cell lines.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内