[摘要]:approach that allows access for several representatives of the iridal family as well as diversely substituted analogs. The success of the proposed synthetic plan depends upon the effortless stereoselective establishment of the trans C10/C11 di-Me relationship in B-ring moiety II using a domino-based methodol. and the highly efficient Miyaura-Suzuki type sp3-sp2 segment coupling II and III, resp.